Stoudt's is a great place. The brewery itself is small, their whole operation is huge and awesome. If you don't know the history, Ed Stoudt started a restaurant, then expanded to antique sales, then he married Carol and she started the brewery. They have an awesome and authentic biergarten, the antiques seem to go on forever and the restaurant has a couple different rooms with different atmospheres.
Dogfish Head's production brewery in Milton, DE is awesome. The giant wood fermentors they age Palo Santo in are pretty crazy and then there is the giant store/tasting room, the steam punk treehouse and bocce ball courts.
The new Tröegs facility in Hershey has a brilliant self guided tour. You enter a hallway with glass on either side from the tasting room, behind the glass is the brewery on one side and a lab on the other. You walk down further and it opens into a bigger room with some tables. The bottling line is behind glass there and barrel aging is going on next to that. If you keep walking, you come out into the store. There is also the Scratch brewery right inside the tasting room along with their hop back system. They just started doing guided tours and I can't wait to go on one, but the way this is set up for self guided tours is great.