If you are using RO water (I do too, since my local water is not great) you definitely need to add salts. RO has basically zero minerals and you need at least 50 ppm of Calcium in every batch for yeast health, though you can go lower for lagers. Use Bru'n Water and adjust the RO water to the style of beer, more gypsum for hoppy beers, more calcium chloride for malty beers, etc.
I argue with guys in my homebrew club who still don't adjust tap water, that beer is 95% water, we pick the best grains, the best hops, good yeast...so why would you ignore the biggest ingredient of all? In my town, my water is very high in sodium and chloride, so if I used it, the sodium would throw off every beer and with the amount of chloride, every hoppy beer would be blah unless I added a lot of gypsum.
Here's an example of adjusting your water, I am brewing a Festbier Friday, BIAB so no sparge, so all added at beginning of mash. I picked yellow full (malty) in Bru'n Water and my additions are:
Gpysum 0.6 grams
Calcium Chloride 4.3 grams
Epsom Salt 0.8 grams
Sodium Metabisulfite 1.0 grams
Lactic Acid 0.8 ml
Which gives me a water profile of:
Calcium 45
Magnesium 3
Sodium 8
Sulfate 56
Chloride 71
SO4/Cl ratio of 0.8 = Malty
pH 5.39 - I target 5.4 pH for lagers and then lower to 5.2 in kettle if needed.