There was a talk at NHC on the myth of cohumulone creating a harsh bitterness.
The argument was that cohumulone has the highest solubility with respect to low pH among other alpha acids. This is relevant because beer pH drops during fermentation from 5.2ish at boil to around 4.2ish after fermentation. Therefore, if you calculate 40 IBUS with a high and a low cohumulone %AA hop, the one having the higher cohumulone content will actually have a higher measured IBU count due to the increased solubility at lower pH. The take away being that it's not a harsher bitterness; it's just higher IBU than the lower cohumulone hop.
The speaker handed out two samples with identical measured IBUS at 33.7 of two hop varieties: 1) high cohumulone; and 2) low cohumulone. The audience opinion was split, but the lower cohumulone hop had higher perceived bitterness at equal measured IBU.
The speaker inferred that the lower cohumulone beer required more hops to achieve the same bitterness. More hops increase polyphenols, which increase perceived bitterness. I'm not sure I buy it, but it was an interesting talk. It would have been nice had he actually presented the solubility differences for the alpha acids as a function of pH.