Depends on your volumes.
Here's a way to help you figure it out assuming you know your volumes:
Preboil gravity points x preboil volume = postboil gravity points x postboil volume
So, if you start with 6.5 gallons preboil:
42 x 6.5 = 60 x postboil volume
Solving for postboil volume gives you 4.55 gallons.
So, you'll have to boil off about 2 gallons, which would take you about 2 hours.