Yes and no. I regularly clean my entire system after a brew. I have a Stay in Place SS manifold that I do not take apart anymore. I do use PBW on my manifold, pumps, MLT, and Brew Kettle. I cycle hot (140) PBW through all of it about for two hours including my Plate Chiller and Hose that I transfer cooled wort to the Fermentor. You have to think of the Hot side and the Cooled side. The Cooled Side is much more important. That being said, I clean everything. Why did I say no? I had a Blickmann brew kettle that had one of those bolted together ball valves. After a year of brewing, I decided to clean it. It was full of gunk and all the seals were brown. It never seemed to effect the brews so it made me think of the Hot Side vs the Cooled Side. You need to be very careful on the Cooled Side, but not so on the hot. In fact, one time a grain bag broke and we had to sweep up the grain off the floor. Beer was good. Another time I stepped into a bucket of wort (pre boil), We called that "sneaker beer". It was fine.