Regulators last a very long time, or at least they should last a long time. They are very simple devices and if properly mainainted, there is not a whole lot that can go wrong. The rubber diaphram is the most susceptible to wear, tear and/or exposure to the beverage if it backs up for any reason. Most regulators are very easy to take apart for inspection, cleaning etc. I do it routinely just to be sure I'm not blowing nasty stuff into my beer along with the CO2. I have one very old regulator that I resurrected from the dead with just a good cleaning and some food grade silicone spray. The silicone restored the diaphragm flexibility so it would seal properly. IMO, the check valves on the regulators can be somewhat hit or miss. I've had beer make it back past the check valve on occasion. I'm not sure why that happens, as it shouldn't. I now take care to make sure that the gas line pressure is higher than the keg pressure when hooking up and the ball valve on the regulator is open, especially if the keg is very full where the short gas in dip tube is submerged or partially submerged.