Off flavours from reused yeast?

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Adamkav

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So this is the first time I have reused yeast, I fermented 2 identical 5gal batches of wort (Blonde ale of 1.060). One batch I used fresh safale05 , the other I reused White labs 001 from a red ale (og 1.062). I am also aware that one would normally go opposite way of styles, eg. blonde to red.
Anyways.. the safale beer turned out great.. some fruity esters and allowing hops to shine through. The white labs on the other hand , I'm getting some off flavours eg. Stale, paper, carboard, slightly metallic? Now I'm wondering if this is at all possible because of the yeast? Or if it has to be some other factor (oxygenation?) Basically I need to know if I ever want to try reusing a yeast cake again (obviously not the same one) ..
 
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