Drop the melanoidan, you'll get plenty of flavor from the MO and it really isn't needed in a bitter of any sort. Hopping looks fine - that's a great hop combo - although I would move the Styrians to 15 and the final EKG to flameout if you want to get any of its floral/spicy aroma.
Thames Valley is fine for yeast, just be sure to pitch a healthy starter and keep your ferment temps in check (64-67F is what I like this at).
